For guys with low testosterone, taking testosterone together with Viagra might not assist their erections more than if they just took Viagra, a brand-new research study program.

" There were great deals of factors to believe that it would work," Boston University scientist Matthew Spitzer, MD, states of the typical practice of integrating the two treatments. "It was unexpected to me that it didn't.".

The research study, released in the Record of Internal Medication, was a good one and the biggest of its kind, "however will it alter practice? In my viewpoint, no," states urologist Jason Hedges, MD, Ph.D., of Oregon Health and Science University in Portland. He was not associated with the research study.

" While low testosterone and [impotence] ED can be associated, they are different concerns, and I treat them as such," states Michael Eisenberg, MD, who likewise was not associated with the research study. "I do not anticipate that dealing with low testosterone will enhance ED, however, it will likely enhance sex drive and interest in sex," states Eisenberg, an assistant teacher of urology at Stanford University School of Medication.

" There is no advantage to including testosterone in [Viagra]," Spitzer states. He keeps in mind, however, that every case is various. "Treatment is an extremely specific circumstance, and this research study does not represent all guys. If you gain from both, you ought to be comfortable continuing this combined treatment.".
Testosterone and Viagra.
Spitzer's group studied 140 guys with low testosterone for 14 weeks. All of the men took Viagra. Some likewise gotten testosterone gel, while others got a placebo.

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Throughout the research study, the men reported how frequently they made love and ranked their sexual complete satisfaction, libido, and orgasms, and their capability to attain and preserve an erection.

In every classification, both groups had comparable ratings. Typically, the men's erectile function is enhanced, with or without testosterone.
Treatment for the men in the research study was "not a total remedy, however, the enhancements were considerable," Spitzer states.

The research study, Spitzer states, likewise advises us that we do not yet understand all the ways in which drugs like Viagra work. One unexpected discovery, he states, is that Viagra (sildenafil) appears to increase testosterone levels rather.
" Prior to this examination, I had actually not thought of sildenafil as a drug that would raise testosterone," states Spitzer. "This raises a lot of concerns. It's hard to state why this occurred, and I'm going to check out it in the future.".

When a client has ED, Hedges states he constantly evaluates for low testosterone. If it shows to be low and the client has other signs of low testosterone, the first thing he typically recommends is testosterone replacement treatment.

" Testosterone appears to raise or switch on signaling paths that are necessary for erections," states Hedges. "What prevails is to attempt testosterone and after that include [Viagra or another ED drug] if you require it. The majority of the time, testosterone will not repair whatever.".

Hedges and Spitzer report no disclosures associated with the research study. Eisenberg reveals getting a drug business grant to study the association between testosterone and health.

estosterone and Viagra

Spitzer's team studied 140 men with low testosterone for 14 weeks. All of the men took Viagra. Some also received testosterone gel, while others got a placebo.

During the study, the men reported how often they had sex and rated their sexual satisfaction, sexual desire and orgasms, and their ability to achieve and maintain an erection.

In every category, both groups had similar scores. On average, the men's erectile function improved, with or without testosterone.

Treatment for the men in the study was "not a complete cure, but the improvements were substantial," Spitzer says.

The study, Spitzer says, also reminds us that we don't yet know all the ways in which drugs like Viagra work. One surprising discovery, he says, is that Viagra (sildenafil) appears to increase testosterone levels somewhat.

"Prior to this investigation, I had not thought of sildenafil as a drug that would raise testosterone," says Spitzer. "This raises a lot of questions. It's difficult to say why this happened, and I'm going to look into it in the future."

When a patient has ED, Hedges says he always tests for low testosterone. If it proves to be low and the patient has other symptoms of low testosterone, the first thing he often prescribes is testosterone replacement therapy.

"Testosterone seems to raise or turn on signaling pathways that are important for erections," says Hedges. "What's common is to try testosterone and then add [Viagra or another ED drug] if you need it. Most of the time, testosterone won't fix everything."

Hedges and Spitzer report no disclosures related to the study. Eisenberg discloses receiving a drug company grant to study the association between testosterone and health.

Source: webmd