While researching some nootropics we often get confused as there are many and we don’t know which one is best for us. Although your doctor gets to decide here, you should be aware of the different types of nootropics before we dive into the comparative analysis.
Let's look at the list of best-quality nootropics that you can research.
- Noocube: Best for focus, memory and brain fog
- Vyvamind: Used in ADHD
- Mind Lab Pro: It is best used for creativity and learning.
- Hunter focus: Smart drug for professionals
- Performance lab mind: It is used to reduce mental fatigue
- Onnit Alpha Brain: Used for fast cognitive processing
- Focus Factor: Most popular OTC stimulant
- Qualia Mind: Premium nootropic brand with good reviews
- Nootropics by Thesis: Highly rated brain pill
And moreover, modafinil has many names. It is sold under the brand name Provigil. Both Vyvanse and Provigil are used as nootropic stimulants. However, they are employed in remedying various ailments. Provigil is given to people who are too sleepy because of narcolepsy, shiftwork sleep disorder, or obstructive sleep apnea/hypopnea syndrome to help them stay awake.
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However, Vyvanse is a stimulant that is used to treat ADHD. It helps lessen symptoms like impulsivity and hyperactivity and improves focus. It can also help people with moderate to serious Binge Eating Disorder (BED) have more days per month when they don't binge. Vyvanse should be used along with other treatments like counselling or behavioural therapies. However, it is important to keep in mind that it has the potential to become addictive, and both adults and children have had major cardiac side effects.
Let me tell you, there are quite similarities between the two. They both have a nootropic effect and are used to treat attention deficit hyperactivity disorder and sleep disorders. Modafinil is primarily prescribed for the treatment of sleep disorders like narcolepsy. However, it has many off-label uses like reducing the hypersensitivity symptoms of ADHD and other sleep disorders. Both of these substances are considered stimulants. Whereas, Vyvanse is an amphetamine which increases the chances of dependency on them. Now that you know where these drugs are used, let's check the mechanism of action of each drug for better understanding.
Mechanism of Action: Modafinil
Let’s talk science here, shall we? Modafinil may increase alertness by stimulating the release of orexin neuropeptides and histamine from the lateral hypothalamus and tuberomammillary nucleus, similar to an atypical, selective weak dopamine reuptake inhibitor. It is responsible to improve some aspects of thinking, planning, decision-making and cognition.
It usually starts showing the action after 30-60 min of ingestion. Modafinil affects different parts of the brain, like the hypothalamus, hippocampus, and amygdala, to make the person feel more awake and energized. Adults and teenagers more than 17 years of age consume 200mg tablet of modafinil a day, once in the morning. It eventually depends on your doctor and your symptoms. In the form of metabolites, 80% of the dose is found in the urine.
Mechanism of action: Vyvanse
Dextroamphetamine can be made from lisdexamfetamine. The active form of this drug stops norepinephrine and dopamine from getting back into the presynaptic cell and makes more of these monoamines leak out into the extraneuronal space. In vitro Label, the parent drug, lisdexamfetamine, doesn't connect to the sites where norepinephrine and dopamine are taken back up. Attention Deficit Hyperactivity Disorder (ADHD) treatment is not fully understood in terms of how it works.
Both the neurotransmitters used help to boost alertness, increase focus and sustains thought, process and motivation. Vyvanse helps the different parts of the brain talk to each other better. Vyvanse is a drug made from amphetamine, just like Adderall.
Instructions to use the medications
Modafinil
It comes in 3 doses with different names
- Modafinil 100 mg
- Modafinil 150 mg (Armodafinil)
- Modafinil 200 mg
How much you take is judged by the severity of your symptoms. Do not change the concentration of the doses without consulting the doctor. Since it is a stimulant it has its own set of cons after extreme consumption.
Some people decide to double the dose. It is not recommended to do so due to the increased chances of side effects. Within the 200-400 range the side effects are minimal and manageable.
Vyvanse
It also comes in 3 doses. However, the potency is significantly different. Vyvanse is highly potent in comparison with modafinil. Because different people respond differently to drugs, your doctor will tailor your dosage to your specific needs. Typically, a doctor will have you take 20 milligrams twice a day for two weeks before scheduling another appointment.
After two weeks, if the medicine hasn't helped, you'll get an increase to 40 mg and try again.
Side effects of Modafinil
As I said, excessive usage of modafinil can have deleterious side effects. Common side effects include:
- Headache
- Dizziness
- Nausea
- Feeling nervous
- Back pain
- Diarrhea
- Runny nose
- Upset stomach and indigestion
- Trouble sleeping
Severe side effects include:
- Extreme sensitivity to allergens
- Skin reactions so severe they hinder movement
- Driving impairment
- Heart problems
Side effects of Vyvanse
- Anxiety
- Dry mouth
- Diarrhea
- Dizziness
- Tingling sensation in the feet
- Poor appetite
- Shortness of breath
- Stomach pain
- Fast heartbeat
If you experience any adverse effects that are bothersome or persistent, consult your doctor.
These Vyvanse adverse reactions are not exhaustive.
Modafinil vs Vyvanse
Main use:
They are used as a stimulant and provide energy to focus and concentrate. Both Modafinil and Vyvanse are available by prescription only in the United States. In order to legally possess these drugs you need a professional certification from your healthcare provider.
One study shows that adults with ADHD when given Vyvanse in a trial and other amphetamines were effective. While modafinil acts like a placebo.
Comparison
Vyvanse is very habit-forming and is very potent. Since it belongs to the class of amphetamines, they are known for its habit developing potential. However, modafinil dependence is not quite known.
Modafinil is approved for various narcolepsy and sleep disorders. While Vyvanse is the drug of choice for ADHD. Additionally, Vyvanse is also approved for Binge eating disorder patients.
The side effects of both these drugs slightly differ. According to research, modafinil has fewer side effects than Vyvanse. Vyvanse has more potent side effects. Hence it is necessary to consult your doctor to treat these side effects.
In terms of how it works in the body, Vyvanse is stronger than modafinil. A powerful group of drugs is called amphetamines. Vyvanse is widely used as an ADHD medicine. Dopamine levels are raised a little more effectively than with modafinil, but it lacks most of the modafinil's other advantages. Vyvanse, for instance, has many drawbacks and doesn't prevent fatigue nearly as well as modafinil.
What is suitable for you?
If you want to have a comparative discussion regarding which is better, it is important to consult your doctor. Generally, modafinil as a nootropic is preferred for better concentration, focus and attention. Given these factors, we chose to focus on modafinil as the ideal nootropic (or "smart drug").
The use of “smart drugs” is on the rise exponentially. However, its abuse is also quite frequent. They are sometimes also taken in combination with other nootropics. Even though more research is needed to figure out how to make the side effects as mild as possible.
